). Significant expression of SQSTM1/p62 protein is connected to lousy prognosis in epithelial ovarian cancer
). Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages defend against atherosclerosis
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Efficient proteostasis is important for somatic upkeep, and its drop for the duration of getting older causes cellular dysfunction and disease. Selective autophagy can be a type of autophagy mediated by receptors that target precise cargoes for degradation which is an essential course of action to maintain proteostasis. The protein Sequestosome one (p62/SQSTM1) is actually a classical selective autophagy receptor, but Additionally, it has roles during the ubiquitin-proteasome technique, mobile metabolism, signaling, and apoptosis. p62 is ideal noted for its position in clearing protein aggregates via aggrephagy, nonetheless it has recently emerged being a receptor for other forms of selective autophagy for example mitophagy and lipophagy.
). Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent fashion
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Notably, p62 has context-dependent impacts on organismal getting older and turnover of p62 commonly displays Energetic proteostasis. On this evaluation, we highlight latest developments in comprehension the purpose of p62 in coordinating the ubiquitin-proteasome process and autophagy. We also discuss positive and negative effects of p62 on proteostatic position and their implications on growing older and neurodegeneration. Finally, we relate the link between defective p62 and diseases of growing old and take a look at the utility of focusing on this multifaceted protein to realize proteostatic Rewards.
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Refined alterations may Management their “precedence” for the proteasome, resulting in altered degradation prices that provide rise to a number of biological features [39].
). Arsenic induces p62 expression to sort a constructive responses loop with Nrf2 in human epidermal keratinocytes: implications for protecting against arsenic-induced skin cancer
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